Research and Development

Company Title Company Description City
3i-Nano

3i Nano develops point-of-care devices for disease diagnostics and protein detection.

Greensboro
410 Medical Inc.

410 Medical Innovation is developing technology for rapid infusion of fluids for hospital, transport and military healthcare providers, enabling clinicians to quickly and effectively resuscitate critically-ill patients.

Durham
908 Devices Inc.

908 Devices develops and makes chemical analysis products such as handheld chemical detection tools, compact analyzers and separation devices.

Carrboro
AC Thera LLC

AC Thera is developing drugs to neutralize bacterial toxins for the treatment of diseases with high mortality.

Wake Forest
AccuGenomics Inc.

AccuGenomics develops gene expression tests to diagnose and monitor cancer treatment. Its technologies include Standardized Nucleic Acid Quantification (SNAQ) for quantitative PCR and Standardized RNA Sequencing (STARSEQ) for NGS platform analysis.

Wilmington
Achelios Therapeutics Inc.

Achelios Therapeutics develops novel topical therapeutics for the treatment of inflammatory pain, including migraine and temporomandibular joint disorder pain.

Durham
Actus Therapeutics Inc.

Actus Therapeutics develops gene therapies for rare diseases including Pompe disease and epilepsy.

Chapel Hill
Adámas Nanotechnologies Inc.

Adámas Nanotechnologies develops and produces fluorescent nanodiamond particles for life science, medical and industrial applications, including life science research, drug delivery, bioimaging, anti-counterfeiting, oil additives and cosmetics.

Raleigh
Adhezion Biomedical LLC

Adhezion Biomedical develops and produces cyanoacrylate-based medical adhesive, wound care and microbial barrier products for connective tissue (human skin). The company's manufacturing and research facility is located in Hudson, N.C.

Hudson
Adrenas Therapeutics Inc.

Adrenas Therapeutics is developing a gene therapy for the treatment of a monogenic disease that presents in childhood.

Raleigh
Adroit Pharmaceutical Development LLC

Adroit Pharmaceutical Development identifies new and improved formulations and process technologies. Its primary focus is on inhalation and dermatological product development.

Durham
Advanced Animal Diagnostics Inc.

Advanced Animal Diagnostics (AAD) develops and commercializes diagnostics to detect and manage disease states, reproductive, nutritional and overall health status of production animals.

Morrisville
Advanced Chemotherapy Technologies Inc.

Advanced Chemotherapy Technologies, a UNC startup, has developed a novel device for infusing chemotherapies directly into poorly-vascularized pancreatic tumors.

Raleigh
Aegis Surgical Ltd.

AEGIS is developing a less invasive access system that facilitates percutaneous transaortic transcatheter aortic valve replacement (pTAo-TAVR).

Durham
AegisCN LLC

AegisCN develops technologies and treatments targeting neurological diseases and inflammation.

Durham
Aerie Pharmaceuticals Inc.

Aerie Pharmaceuticals discovers, develops and commercializes first-in-class therapies for the treatment of patients with glaucoma.

Durham
Aestas Pharma Inc.

Asetas Pharma develops novel diagnostic imaging and disease-modifying therapeutic agents to enable the early treatment and reversal of Alzheimer’s and Parkinson’s disease when clinical signs are not yet pronounced.

Lewisville
Affinergy LLC

Affinergy develops peptide-based technologies, including diagnostic products, research tools and therapeutic drug monitoring products for use by clinicians and researchers.

Morrisville
AgBiome Inc.

AgBiome uses its proprietary Genesis platform to collect, isolate and analyze microbes for use in the discovery and development of biologicals and traits for protecting crops.

Research Triangle Park
Agile Sciences Inc.

Agile Sciences is developing a technology for the treatment of antibiotic-resistant, life-threatening infections.

Raleigh
AI Tracking Solutions LLC

AI Tracking Solutions develops a single-particle tracking software that tracks entities including nanoparticles, viruses, bacteria and cells within fluids and biological samples, and generates individual traces and statistical analysis of the traces.

Carrboro
AimMax Therapeutics Inc.

AimMax Therapeutics researches and develops biopharmaceuticals for the treatment of infection, inflammation and pain through in-licensing or co-development with strategic partners.

Research Triangle Park
Ajinomoto North America

Ajinomoto North America manufactures pharmaceutical-grade amino acids and custom-blended amino acid mixtures.

Raleigh
Akros Medical Inc.

Akros Medical develops orthopedic medical devices.

Durham
Alcami Corporation

Alcami provides contract drug development and manufacturing services, including API manufacturing, formulation development, analytical chemistry and solid dose and parenteral drug manufacturing for both clinical and commercial markets.

Wilmington
Alderon BioSciences Inc.

Alderon Biosciences develops point-of-care diagnostics.

Beaufort
ALG Therapeutics LLC

ALG Therapeutics develops pharmaceutical products for pain disorders.

Chapel Hill
Algaen Corp.

Algaen uses microalgae to develop, produce and market products and technologies for the nutraceutical, pharmaceutical and bio-energy industries.

Winston-Salem
Allergy Partners Extract Laboratory

Allergy Partners' Extract Laboratory produces extracts that are used to treat allergic disease, asthma and immunology.

Asheville
Almac Diagnostics LLC

Almac offers services for biomarker discovery, assay development/validation/testing and companion diagnostic co-development. Testing platforms include NGS, Microarray, qPCR and IHC. Regulatory and bioinformatics services are also available.

Durham
ALP Life Sciences Inc.

ALP Life Sciences has formulated and markets a High-3 fish oil supplement to increase omega-3 absorption and bioavailability for the treatment of fatty liver disease and inflammatory diseases.

Black Mountain
AlphaSyx Therapeutics Inc.

AlphaSyx Therapeutics is developing novel medicines that target cholinergic receptors to prevent and treat diseases of inflammation, initially neuroinflammation resulting in Postoperative Cognitive Decline (POCD).

Winston-Salem
AlphaVax Inc.

AlphaVax develops vaccine technology with applications in infectious disease, cancer and biodefense threats.

Research Triangle Park
Altavant Sciences

Altavant is developing a treatment for pulmonary arterial hypertension.

Durham
Alterna Therapeutics Inc.

Alterna Therapeutics develops therapeutics to treat diabetes and obesity.

Durham
Altis BioSystems Inc.

Altis Biosystems has developed a stem cell technology that recreates the human intestinal epithelium in a 2D or 3D layer of intestinal stem and differentiated cells, which can be used for compound screening, microbiome research and disease modeling.

Chapel Hill
Amyris Inc.

Amyris converts plant sugars into hydrocarbon molecules and produces specialty ingredients and consumer products. This site uses renewable biofarnesene to manufacture products such as biofuels, lubricants, cosmetics and other specialty chemicals.

Leland
Andersen Products Inc.

Andersen Products sells and services the Anprolene and EOGas lines of 100% ethylene oxide gas sterilizers. They also provide contract packaging and sterilization services for device manufacturers.

Haw River
AnelleO

AnelleO is developing a 3D printed intravaginal ring that can be used as a platform for treating a wide range of women's health conditions.

Chapel Hill
Anémot Therapeutics Inc.

Anémot Therapeutics develops therapeutics for acute and chronic inflammation. Its lead product is being developed for severe RSV infections, cystic fibrosis and other diseases of lung injury.

Chapel Hill
Apeirolux Pharmaceutical Inc.

Apeirolux Pharmaceutical is developing a tumor-cell selective topical skin cream for the treatment of skin cancer.

Research Triangle Park
Appealing Products Inc.

Appealing Products develops products for forensics and personal protection from toxic materials such as inorganics, gases and poisons in foods, animal feeds and liquids.

Raleigh
Apple Pharms Ingredients Inc.

Apple Pharms Ingredients discovers natural bioactive ingredients and functional foods for nutritional and medicinal purposes. Apple Pharms also provides contract development and drug discovery services.

Asheville
Applied Catheter Technologies Inc.

Applied Catheter Technologies develops drug-coated medical devices that inhibit scar formation. The company's first products under development are catheters for male urethral stricture and devices that inhibit abdominal adhesions.

Winston-Salem
Applied LifeSciences & Systems Poultry Inc.

Applied LifeSciences & Systems Poultry develops automated bio-system solutions for detecting, targeting and delivering vaccines to poultry. ALS-S technology aims to reduce the need for antibiotics by improving vaccination delivery.

Raleigh
Arbiom Inc.

Arbiom develops technologies that convert residues from agriculture and forestry into the intermediates required for the production of biofuels, biomaterials and green chemicals. The Raleigh office is Arbiom's application center.

Durham
Arcato Laboratories Inc.

Arcato Laboratories develops specialty oral healthcare products. Its first product is a sustained-release medicated wax that treats oral discomfort caused by orthodontic appliances.

Durham
Ardeal Pharma Inc.

Ardeal Pharma is a virtual pharma company developing patented stabilized sulforaphane for the dermal pharmaceutical and cosmetic markets.

Brevard
Ardeal Research Institute

Ardeal Research Institute is a non-profit organization that develops drug discovery capabilities of the natural resources in Western North Carolina. The Institute has collaboration agreements in place with Brevard College and the N.C. Arboretum.

Brevard
Argos Therapeutics Inc.

Argos Therapeutics develops individualized immunotherapies for the treatment of cancer and infectious diseases using its Arcelis technology platform.

Durham
Array BioPharma Inc.

Array BioPharma discovers, develops and commercializes targeted, small-molecule drugs to treat cancer.

Morrisville
Arrevus Inc.

Arrevus is developing designer proline-rich antimicrobial peptide chaperone-protein inhibitors (DCPs) to treat diseases for which antibiotic resistance has clinical implications.

Raleigh
Arrivo BioVentures LLC

Arrivo BioVentures accelerates biologics and small molecules from IND/phase one through proof-of-concept, with biologics in development for dermatologic conditions and hearing loss.

Morrisville
ARSPIChem LLC

Arspichem offers chemical product services to pharma, biotech industries, universities and research organizations to support drug discovery. Products and services include organic molecules, custom synthesis and pharmaceutical screening libraries.

Research Triangle Park
Artizan Biosciences Inc.

Artizan is developing a platform for identifying and targeting pathogenic intestinal bacteria, with a focus on inflammatory bowel disease and potential applications in autoimmune diseases, obesity, skin, lung and central nervous system diseases.

Durham
Arysta LifeScience North America LLC

Arysta LifeScience develops, manufactures and distributes biological and chemical crop protection and plant nutrition products.

Cary
Ascent Bio-Nano Technologies Inc.

Ascent Bio-Nano Technologies develops cell and particle separation research tools and medical devices.

Research Triangle Park
Asklepios BioPharmaceutical Inc.

Asklepios BioPharmaceutical (AskBio) develops protein- and cell-based therapies using a proprietary technology platform called Biological Nano Particles (BNP).

Research Triangle Park
Asystbio Laboratories LLC

Asystbio Laboratories uses next-generation DNA sequencing and proprietary algorithms to count mutations in leukemic cells.

Chapel Hill
ATEX Technologies Inc.

ATEX manufactures custom engineered implantable textile components for medical devices. Components are manufactured using weaving, knitting, braiding, and non-woven technologies. Raw materials include polyester, bio-absorbable polymers and metals.

Pinebluff
Atlantic Medical Inc.

Atlantic Medical develops nutraceutical products and devices to address ocular diseases.

Wrightsville Beach
Atlas Regeneration Inc.

Atlas Regeneration develops bioinformatics platforms for drug discovery related to regenerative medicine and stem cell research. Atlas Regeneration also screens drugs in silico for drug repositioning.

Winston-Salem
Atox Bio Inc.

Atox Bio develops novel immunomodulators to treat critically ill patients. Initial focus is on patients with Necrotizing Soft Tissue Infections.

Chapel Hill
Atrium Health Division of Therapeutic Research and Development

The Division of Therapeutic Research and Development at Atrium Health conducts clinical studies, patient-focused translational research and outcomes research.

Charlotte
Attagene Inc.

Attagene has developed a pathway profiling technology to evaluate the impact of pharmaceuticals and environmental chemicals on over 100 transcription factors and 48 nuclear receptors.

Morrisville
Atticus LLC

Atticus, a CSE Life Science Company, develops, manufactures and markets post-patent fungicides, herbicides and insecticides.

Cary
Aurobindo Pharma USA Inc.

Aurobindo Pharma is a generic drug manufacturer. Aurobindo develops inhalation and dermatological products from the company's U.S. research and development headquarters in North Carolina.

Durham
Avertica Inc.

Avertica develops compounds and polymers for electronic device applications, including the development of biomimetic and bio-based electronic materials.

Research Triangle Park
Avila Inc.

Avila is developing rapid hair removal pad technology for use prior to the placement of defibrillator pads on victims of sudden cardiac arrest.

Durham
Avioq Inc.

Avioq develops and manufactures FDA-approved and CE-marked immunodiagnostic assays. Products include HIV and HTLV assays, recombinant proteins and synthetic peptides and labware supplies. Avioq also offers contract IVD development and manufacturing.

Research Triangle Park
Avior Inc.

Avior Bio is an developing a nanoparticle-based drug delivery technology to deliver lipophilic drugs with high bioavailability. It is testing its technology using a molecule for the treatment of pruritus in chronic kidney disease.

Holly Springs
Avolynt Inc.

Avolynt is developing a novel SGLT2 inhibitor for the treatment of nonalcoholic steatohepatitis (NASH) and type 2 diabetes.

Research Triangle Park
Axovant Sciences Inc.

Axovant Sciences develops gene therapies to treat neurologic conditions.

Durham
Baebies Inc.

Baebies develops and delivers products and services based on digital microfluidics and other technology to advance newborn screening and pediatric testing worldwide.

Durham
Ballek Biologics LLC

Ballek Biologics is developing a therapeutic to reverse opioid overdose.

Raleigh
Banner Life Sciences LLC

Banner Life Sciences develops formulation technologies (gelcaps, tablets and sterile injectables) and licenses and markets prescription, over-the-counter and nutritional products.

High Point
Barbaresco Pharma LLC

Barbaresco Pharmaceuticals is a target drug discovery company focused on obesity, cardiovascular and metabolic diseases.

Chapel Hill
BASF Agricultural Solutions

BASF's Agricultural Solutions division conducts seeds, traits and plant biotechnology research with a focus on yield and quality traits in major crops. Its RTP campus also houses a bee care center.

Morrisville
Bavarian Nordic Inc.

Bavarian Nordic develops, manufactures and commercializes cancer immunotherapies and vaccines for infectious diseases.

Morrisville
Bayer Environmental Science

Bayer Environmental Science, a unit of Bayer CropScience, develops and markets pest-, weed- and disease-control products for non-crop situations. This facility supports development, testing and training for its consumer and professional products.

Clayton
BD Technologies and Innovation

BD Technologies and Innovation develops technologies for parenteral drug delivery, advanced diagnostics, smart medical devices, genomic research and supports external innovation. The RTP site is BD's corporate technology R&D and innovation center.

Research Triangle Park
BENANOVA Inc.

BENANOVA develops antimicrobial nanotechnology products for the disinfectant, cosmetic and agricultural industries.

Raleigh
Benson Hill Biosystems Inc.

Benson Hill Biosystems has developed a crop design platform that combines machine learning, big data, genome editing and plant biology to help plant researchers predict and control traits, and bring crop and ingredient improvements to market faster.

Research Triangle Park
Bent Creek Institute Inc.

The Institute conserves and develops plant biodiversity assets and maintains the North Carolina Arboretum’s Bent Creek Germplasm Repository. It also administers the U.S. Botanical Safety Laboratory, a consortium of university botanical research sites.

Asheville
BioAesthetics Corporation

BioAesthetics Corporation is developing a nipple areolar complex graft that allows the patients' cells to grow into the graft for use in breast reconstruction.

Research Triangle Park
BioCryst Pharmaceuticals Inc.

BioCryst Pharmaceuticals designs and develops novel, small-molecule oral drugs that block key enzymes to treat rare diseases. The Durham location houses BioCryst's clinical, regulatory and executive teams.

Durham
BioCytics Inc.

BioCytics researches and develops personalized cellular immunotherapy cancer therapies with the latest technology and equipment. BioCytics also offers contract R&D, and is incubated within the Carolina BioOncology Institute.

Huntersville
BioDelivery Sciences International Inc.

BioDelivery Sciences is a specialty pharmaceutical company with a focus in the areas of pain management and addiction. The company's lead products utilize a buccal film delivery system.

Raleigh
Biofluidica Inc.

Biofluidica is developing novel instrumentation for the isolation and analysis of circulating biomarkers, including circulating tumor cells, in cancer patients.

Research Triangle Park
BioIVT

BioIVT provides biological specimens, specializing in control and disease state human and animal tissues. This site develops and commercializes cell-based drug toxicity-testing products for pharmaceutical development, based on hepatocyte technologies.

Durham
BioKier Inc.

BioKier develops proprietary adjuvant treatments for diabetes and related disorders. BioKier has identified a therapeutic opportunity based on gastric bypass surgery and is developing a novel treatment for diabetes.

Chapel Hill
BioLink Life Sciences Inc.

BioLink provides contract product development support through custom synthesis and testing.

Cary
BioMarck Pharmaceuticals Ltd.

BioMarck develops drugs to treat pulmonary diseases and disorders, such as chronic obstructive pulmonary disease, ARDS, cystic fibrosis and lung cancer.

Durham
bioMASON Inc.

bioMASON develops masonry material from a nonpathogenic bacterium which induces cement materials in between aggregates such as sand.

Research Triangle Park
BioMedomics Inc.

BioMedomics develops point-of-care (POC) diagnostics, with a focus on immunologically-based disease-specific tests and advanced quantitative POC platforms.

Durham
bioMérieux Inc.

bioMérieux develops in vitro products to diagnose infectious diseases, cancer and cardiovascular disease and to detect microorganisms in agri-foods, pharmaceuticals and cosmetics.

Durham
BioResource International Inc.

BioResource International (BRI) designs, develops and manufactures unique enzymes that help poultry and swine producers optimize animal nutrition and gut health.

Durham
Biorg Inc.

Biorg is developing and commercializing organoid technology for use in life science applications such as diagnostics, drug screenings and toxicology.

Winston-Salem
BioRxn LLC

BioRxn develops NMR-based metabolomic technology, including bioreactor and artificial liver systems, for non-invasive monitoring of metabolic biomarkers. BioRxn also provides conventional metabolomic services.

Chapel Hill
Biotality

Biotality develops biological and natural products for crop protection. Its first product is a proprietary organism that overproduces a fungicidal exudate, with applications in the seed protectant and post-harvest markets.

Durham

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