Digestive System and Gastrointestinal Diseases

Company Title Company Description City
ALP Life Sciences Inc.

ALP Life Sciences has formulated and markets a High-3 fish oil supplement to increase omega-3 absorption and bioavailability for the treatment of fatty liver disease and inflammatory diseases.

Black Mountain
Altis BioSystems Inc.

Altis Biosystems has developed a stem cell technology that recreates the human intestinal epithelium in a 2D or 3D layer of intestinal stem and differentiated cells, which can be used for compound screening, microbiome research and disease modeling.

Chapel Hill
Artizan Biosciences Inc.

Artizan is developing a platform for identifying and targeting pathogenic intestinal bacteria, with a focus on inflammatory bowel disease and potential applications in autoimmune diseases, obesity, skin, lung and central nervous system diseases.

Durham
CELLF-Bio LLC

CELLF-Bio is developing a novel regenerative medicine-based therapy for fecal incontinence.

Winston-Salem
CMP Pharma Inc.

CMP develops, manufactures and commercializes specialty pharmaceuticals, focused on niche liquid and topical products that solve unmet patient needs.

Farmville
Cook Medical

Cook Medical develops and manufactures devices used in gastrointestinal endoscopy to diagnose and treat esophageal, gastric, pancreatic, biliary and colonic disorders.

Winston-Salem
Deep Blue Medical Advances Inc.

Deep Blue Medical Advances develops a surgical mesh for hernia repair and other medical device technologies from Duke University.

Durham
DILIsym Services Inc., a Simulations Plus company

DILIsym Services provides consulting services and proprietary software to the pharmaceutical and biotech industries to develop safer and more effective drug therapies.

Research Triangle Park
HepatoSys Inc.

HepatoSys develops technologies for functional restoration of donor livers for use in transplantation and research, focusing on methods for expanding availability of quality human hepatocytes for research and toxicity testing.

Cornelius
Ideal Health Biotechnology LLC

Ideal Health Biotechnology researches and develops dietary supplements made from plant-based compounds, including products derived from grape seed extract and algae for digestion, eye disease and diabetes.

Kannapolis
Innovate Biopharmaceuticals Inc.

Innovate Biopharmaceuticals is developing novel medicines for autoimmune/inflammatory disease.

Raleigh
Locus Biosciences Inc.

Locus Biosciences is developing next-generation CRISPR technology for programmed cell death to kill target bacteria. This platform enables the development of therapeutics for disease areas ranging from resistant bacterial infections to the microbiome.

Research Triangle Park
Patrin Pharma Inc.

Patrin Pharma develops pharmaceutical products, primarily oral dosage forms for gastrointestinal, cardiovascular, antiviral, antibacterial and central nervous system indications.

Salisbury
Perspectum Diagnostics Inc.

Perspectum Diagnostics develops non-invasive medical imaging software tools. Perspectum's LiverMultiScan provides accurate and quantitative liver testing.

Wake Forest
Promethera Biosciences LLC

Promethera Biosciences develops, produces and markets cell therapeutic products, including human liver cells, to treat liver diseases.

Durham
QOL Medical LLC

QOL Medical commercializes existing and complementary new orphan products for metabolic disease and pediatric gastroenterology.

Raleigh
RedHill Biopharma Inc.

RedHill Biopharma develops and commercializes orally-administered, small-molecule drugs for the treatment of gastrointestinal and inflammatory diseases, including cancer. Its Raleigh site is the company's U.S. commercial headquarters.

Raleigh
SoyMeds Inc.

SoyMeds is developing a seed-based expression platform that enables production of protein-based targets that can be used to diagnose and treat disease and address other unmet needs in the healthcare industry.

Charlotte
StrideBio Inc.

StrideBio develops engineered viral vectors for gene therapy for the treatment of rare diseases. StrideBio's technology engine utilizes structure-inspired design to engineer AAV vectors which can escape pre-existing neutralizing antibodies (NAbs).

Durham
T3D Therapeutics Inc.

T3D Therapeutics is developing a disease-modifying drug therapy for Alzheimer’s disease that may improve multiple disease defects. The drug also demonstrates potential as a therapy for nonalcoholic steatohepatitis (NASH).

Research Triangle Park
TransEnterix Inc.

TransEnterix designs and develops flexible instruments and robotics for use in minimally-invasive surgery.

Morrisville
UCB Biosciences Inc.

UCB Biosciences develops therapeutics for the treatment of severe, life-threatening neurological and inflammatory diseases, including epilepsy, Parkinson's disease, rheumatoid arthritis, Crohn's disease, psoriatic arthritis, lupus and osteoporosis.

Raleigh
Verge Therapeutics

Verge Therapeutics develops therapeutics focused on metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

Durham
Vivelix Pharmaceuticals Corp.

Vivelix Pharmaceuticals licenses, develops and commercializes gastroenterology and hepatology treatments.

Morrisville