Immunologic and Inflammatory Diseases

Company Title Company Description City
AimMax Therapeutics Inc.

AimMax Therapeutics researches and develops biopharmaceuticals for the treatment of infection, inflammation and pain through in-licensing or co-development with strategic partners.

Research Triangle Park
Alderon BioSciences Inc.

Alderon Biosciences develops point-of-care diagnostics.

Beaufort
Allergy Partners Extract Laboratory

Allergy Partners' Extract Laboratory produces extracts that are used to treat allergic disease, asthma and immunology.

Asheville
ALP Life Sciences Inc.

ALP Life Sciences has formulated and markets a High-3 fish oil supplement to increase omega-3 absorption and bioavailability for the treatment of fatty liver disease and inflammatory diseases.

Black Mountain
AlphaSyx Therapeutics Inc.

AlphaSyx Therapeutics is developing novel medicines that target cholinergic receptors to prevent and treat diseases of inflammation, initially neuroinflammation resulting in Postoperative Cognitive Decline (POCD).

Winston-Salem
Anémot Therapeutics Inc.

Anémot Therapeutics develops therapeutics for acute and chronic inflammation. Its lead product is being developed for severe RSV infections, cystic fibrosis and other diseases of lung injury.

Chapel Hill
Argos Therapeutics Inc.

Argos Therapeutics develops individualized immunotherapies for the treatment of cancer and infectious diseases using its Arcelis technology platform.

Durham
Array BioPharma Inc.

Array BioPharma discovers, develops and commercializes targeted, small-molecule drugs to treat cancer.

Morrisville
Attagene Inc.

Attagene has developed a pathway profiling technology to evaluate the impact of pharmaceuticals and environmental chemicals on over 100 transcription factors and 48 nuclear receptors.

Morrisville
Bio Products Laboratory USA Inc.

Bio Products Laboratory (BPL) manufactures and distributes plasma-derived products, including intravenous immunoglobulin preparations, coagulation factors and albumin solution. U.S. Commercial Operations for BPL is based in Durham.

Durham
BioCryst Pharmaceuticals Inc.

BioCryst Pharmaceuticals designs and develops novel, small-molecule oral drugs that block key enzymes to treat rare diseases. The Durham location houses BioCryst's clinical, regulatory and executive teams.

Durham
Cellective BioTherapy Inc.

Cellective BioTherapy is developing cellular and monoclonal antibody-based platforms for treating cancers, autoimmunity and immunodeficiency.

Research Triangle Park
Clinical Sensors Inc.

Clinical Sensors (CSI) develops a near-patient test for early detection of sepsis based on nitric oxide measurements from unprocessed blood.

Research Triangle Park
Clinipace Worldwide Inc.

Clinipace provides full-service global clinical development services for drug and medical device programs using its TEMPO eClinical platform, as well as regulatory and strategic consulting.

Morrisville
Cloud Pharmaceuticals Inc.

Cloud Pharmaceuticals designs and develops novel drug molecules using computational design for a wide range of therapeutic areas including cancer, inflammation, CNS disorders and rare diseases.

Research Triangle Park
Cognosci Inc.

Cognosci develops neurorestorative therapies for Alzheimer's disease, multiple sclerosis, traumatic brain injury, nerve crush and other disease and trauma indications.

Durham
Cytex Therapeutics Inc.

Cytex Therapeutics develops bio-artificial devices to treat osteoarthritis and other musculoskeletal diseases.

Durham
Emergo Therapeutics Inc.

Emergo Therapeutics is repurposing drugs for the treatment of acute inflammation.

Durham
Endacea Inc.

Endacea develops A1 adenosine receptor antagonists as drug candidates for renal impairment and inflammation, including sepsis and asthma.

Research Triangle Park
Exodos Life Science Partners

Exodos Life Sciences advances product concepts through the 505(b)(2) process to early clinical proof-of-principle and sale. Exodus specializes in topical formulations for the treatment of pain and inflammation, cold sores and nail fungis.

Chapel Hill
FusionBio Inc.

FusionBio develops novel treatments for immune-mediated diseases, including cancer and autoimmunity.

Chapel Hill
Genencine Therapeutics LLC

Genencine Therapeutics develops mRNA vaccines for the prevention and treatment of cancer, viral diseases and autoimmune diseases, as well as mRNA therapeutic drugs for genetic diseases.

Durham
Global Vaccines Inc.

Global Vaccines is a not-for-profit company that develops vaccines against developing-country diseases such as HIV/AIDS, polio, dengue fever, malaria and viral diarrhea (rotavirus).

Durham
Grifols

Grifols develops and produces plasma-derived medicines to treat chronic and acute conditions in the therapeutic areas of immunology, pulmonology, hematology, thrombolytics and neurology.

Research Triangle Park
Grifols (Clayton)

Grifols' Clayton plant is the company's primary manufacturing facility, producing proteins to treat rare diseases including immune deficiencies and genetic emphysema.

Clayton
GSK

GlaxoSmithKline develops and manufactures vaccines, medicines and consumer healthcare products for the treatment of infectious and respiratory diseases, central nervous system disorders, immuno-inflammation, diabetes and cancer.

Research Triangle Park
Gusto Global LLC

Gusto Global discovers and develops microbiome therapeutics for next-generation immune-modulation.

Research Triangle Park
Heat Biologics Inc.

Heat Biologics develops combination therapies for the treatment of cancer. Heat Biologics is focused on T cell-stimulating therapeutic platform technologies used in combination with checkpoint inhibitors.

Durham
Indexus Biomedical LLC

Indexus Biomedical designs, develops and manufactures instrument systems, reagents and assays for in vitro diagnostics, initially focusing on the hematology and immunology markets.

Morrisville
Innovate Biopharmaceuticals Inc.

Innovate Biopharmaceuticals is developing novel medicines for autoimmune/inflammatory disease.

Raleigh
Kaio Therapy LLC

KAIO Therapy develops immunotherapy technology to treat solid tumors.

Raleigh
Lundbeck NA Ltd.

Lundbeck is a pharmaceutical development company that acquires and develops products for the treatment of various human diseases, including central nervous system disorders.

Charlotte
Mastezellen Bio Inc.

Mastezellen Bio is developing therapeutics for the treatment of diseases and disorders with mast cell involvement.

Research Triangle Park
MicroElastic Ultrasound Systems Inc.

MicroElastic Ultrasound Systems is developing an ultrasound device to measure the progression or regression of graft-versus-host-disease (GVHD).

Durham
Mucommune LLC

Mucommune researches improved protection against infectious diseases transmitted at mucosal surfaces. Mucommune's current focus is a method to prevent sexually transmitted infections using monoclonal antibodies encapsulated in a polymeric capsule.

Chapel Hill
North Carolina Clinical Research

North Carolina Clinical Research conducts phase one through four trials at its outpatient clinical research facility. Study indications include allergy (seasonal and perennial), asthma, COPD, vaccine, migraine and bioequivalent studies.

Raleigh
Novan Inc.

Novan develops therapies for dermatological conditions using its nitric oxide-releasing nanoparticle technology.

Durham
NuBioPharma LLC

NuBioPharma develops and formulates novel liquid medications with child-friendly flavors for debilitating orphan diseases. Therapeutic areas include gout, pulmonary arterial hypertension and thrombocythemia.

Sanford
OliVentures Inc.

OliVentures is developing olive oil polyphenol and omega-3 fatty acid supplements and products to support cardiovascular, breast and joint health.

Raleigh
Pfizer Inc. (Sanford)

Pfizer's Sanford facility manufactures clinical trial and commercial drug substance materials for conjugate vaccines.

Sanford
PhotonMD Inc.

PhotonMD is developing photomedicine devices for aesthetic applications and to treat chronic autoimmune and inflammatory diseases and other conditions.

Morrisville
Pique Therapeutics Inc.

Pique Therapeutics develops therapeutic vaccines for the treatment of cancer.

Durham
Qura Therapeutics LLC

Qura Therapeutics is discovering therapeutics for curing HIV/AIDS. Qura is a joint venture between GSK and UNC Chapel Hill, and provides financial, material and development support for the therapies that emerge from research at the UNC HIV Cure Center.

Chapel Hill
RedHill Biopharma Inc.

RedHill Biopharma develops and commercializes orally-administered, small-molecule drugs for the treatment of gastrointestinal and inflammatory diseases, including cancer. Its Raleigh site is the company's U.S. commercial headquarters.

Raleigh
Renovion Inc.

Renovion develops therapies for lung transplant patients and chronic inflammatory airway diseases including cystic fibrosis, asthma and COPD.

Durham
Stallergenes Greer

Stallergenes Greer develops and distributes animal and human allergy immunotherapy products and services.

Lenoir
TregTherapeutics Inc.

TregTherapeutics develops tolerogenic therapies to treat autoimmune disesase. The company is currently developing a tolerogenic vaccine to eradicate multiple sclerosis.

Chapel Hill
UCB Biosciences Inc.

UCB Biosciences develops therapeutics for the treatment of severe, life-threatening neurological and inflammatory diseases, including epilepsy, Parkinson's disease, rheumatoid arthritis, Crohn's disease, psoriatic arthritis, lupus and osteoporosis.

Raleigh
Worldwide Clinical Trials Inc.

Worldwide Clinical Trials provides phase one through phase four drug development services to the pharmaceutical and biotechnology industries.

Morrisville
Zylera Pharmaceuticals LLC

Zylera Pharmaceuticals, a division of Cerecor, develops, acquires and commercializes prescription products and dietary supplements, specifically for pediatric and women's health.

Research Triangle Park