Combinatorial or Medicinal Chemistry

Affinergy develops peptide-based technologies, including diagnostic products, research tools and therapeutic drug monitoring products for use by clinicians and researchers.

Ajinomoto North America manufactures pharmaceutical-grade amino acids and custom-blended amino acid mixtures.

Asinex designs small-molecule libraries and provides lead optimization, custom synthesis and other chemistry services. The Winston-Salem location is the company's U.S. headquarters.

Avient Biosciences produces cannabinoid-derived products, CBD oil, CBD isolate, water soluble CBD, and other isolated cannabinoid compounds. Avient is in process to be a cGMP compliant extraction facility.

BindusChem offers contract drug discovery and process chemistry projects for clients, synthesis of small molecules for SAR study, focused arrays and scaffolds, as well as chemical development, route scouting, process optimization and validation.

Blue Ridge Institute for Medical Research (BRIMR) researches small-molecule inhibitors of protein kinases and targeted cancer therapies. BRIMR also generates an annual ranking of NIH funding for U.S. medical schools and their departments.

Bright Path Pharmaceuticals is a CDMO that produces pharmaceutical ingredients and medicines, using an AI-enabled continuous flow manufacturing technology.

Cambrex High Point develops and manufactures small-molecule APIs and intermediates for Phase I through III clinical trials. It offers custom organic synthesis, process development, analytical development and cGMP manufacturing services.

Cloud Pharmaceuticals designs and develops novel drug molecules using computational design for a wide range of therapeutic areas including cancer, inflammation, CNS disorders and rare diseases.

Curl Bio develops drugs for the interrelated set of disorders involving Type 2 diabetes, obesity, fatty liver disease, metabolic syndrome and associated complications.

DSK Biopharma provides custom synthesis and medicinal chemistry services. DSK develops and supplies fine chemicals, APIs and intermediates, scaffolds, inhibitors, amino acids, carbohydrates, peptides, coupling reagents and other compounds.

Enzerna Biosciences, Inc is a pre-clinical stage company that is leveraging its proprietary RNA editing technology to develop long-term curative gene therapies for rare genetic disorders such as Huntington's Disease and Myotonic Dystrophy.

Glycan Therapeutics offers synthetic carbohydrates of various lengths to aid researchers investigating multiple therapeutic areas. Glycan also offers custom synthesis and array analysis of heparan and chondroitin sulfate oligosaccharides derivatives.

Heteroz supplies building blocks and screening compounds for research and development and provides custom synthesis of organic and inorganic compounds for the chemical, pharmaceutical and agrochemical industries.

Intarcia Therapeutics is developing a continuous subcutaneous delivery system for the treatment of Type 2 diabetes. The RTP location discovers and develops peptide therapeutic drugs to augment Intarcia's drug delivery platform.

Isosceles Pharmaceuticals is developing parenteral products for delivery of synthetic CBD to treat pain.

LigaTrap Technologies provides proprietary affinity chromatography resins and supporting products. LigaTrap also provides custom services for process development, small batch cell culture, scale up purification and assays.

MedKoo Biosciences supplies biochemical reagents, specializing in small molecule research-used medicines (i.e. non-human-use drugs).

NanoMedica provides ultrasensitive detection reagents and nanotechnology-based drug discovery services and tools to biopharmaceutical companies as well as DNA and RNA sequencing services.

Novex Innovations is a contract development and manufacturing organization (CDMO) supporting medium, small and startup life science companies in the development of their products, from concept through manufacturing and commercialization.

Parion Sciences develops therapies to treat defects of the innate mucosal defense system in respiratory and ophthalmology diseases.

Piedmont Animal Health develops, licenses and markets animal health therapeutics with a focus on major companion animal categories.

Raybow USA (formerly PharmAgra Labs) conducts contract R&D in organic and analytical chemistry for industries including pharma/biotech and electronics. Raybow offers cGMP services including development of APIs for clinical trials and manufacturing.

Ribometrix is a platform therapeutics company discovering small-molecule drugs that target functional RNA structures to create new avenues to treat human disease.

SeaTox Research develops bioassays for the detection of marine toxins and conducts pharmaceutical development through bioprospecting.

Spirovation is a specialty CRO with a focus on the development of breakthrough drugs in respiratory medicine. Spirovation is non-profit, UNC-affiliated entity.

Symmetry Biosciences provides contract research, specialized chemistry services and bioanalytic services to the biotech, pharmaceutical, medical device, agrochemical and fine chemical industries.

Ten63 Therapeutics uses computational chemistry and AI to screen trillions of molecules to discover new therapeutics.

Trana Discovery provides an anti-infective discovery platform that enables its partners to identify novel treatments that possess pathogen-focused spectrums of activity for bacterial, viral and fungal infectious diseases in crops, animals and humans.

Vijaya Pharmaceuticals provides medicinal and synthetic organic chemistry services to the pharmaceutical and allied industries.