Combinatorial or Medicinal Chemistry

Affinergy develops peptide-based technologies, including diagnostic products, research tools and therapeutic drug monitoring products for use by clinicians and researchers.

Ajinomoto North America manufactures pharmaceutical-grade amino acids and custom-blended amino acid mixtures.

Asinex designs small-molecule libraries and provides lead optimization, custom synthesis and other chemistry services. The Winston-Salem location is the company's U.S. headquarters.

Bent Creek Institute is a 501(c)3 non-profit botanical research and economic development organization serving primarily North Carolina-based natural products companies seeking to innovate botanical wellness solutions.

BioAgilytix is a bioanalytical lab specializing in large-molecule bioanalysis, offering PK, immunogenicity, biomarkers and cell-based assays in support of the development and release testing of biologics and small-molecule therapeutics.

Blue Ridge Institute for Medical Research (BRIMR) researches small-molecule inhibitors of protein kinases and targeted cancer therapies. BRIMR also generates an annual ranking of NIH funding for U.S. medical schools and their departments.

Bright Path Pharmaceuticals develops chemical reactor technology for pharmaceutical manufacturing.

Cambrex High Point develops and manufactures small-molecule APIs and intermediates for Phase I through III clinical trials. It offers custom organic synthesis, process development, analytical development and cGMP manufacturing services.

Cloud Pharmaceuticals designs and develops novel drug molecules using computational design for a wide range of therapeutic areas including cancer, inflammation, CNS disorders and rare diseases.

Curl Bio develops drugs for the interrelated set of disorders involving Type 2 diabetes, obesity, fatty liver disease, metabolic syndrome and associated complications.

DSK Biopharma provides custom synthesis and medicinal chemistry services. DSK develops and supplies fine chemicals, APIs and intermediates, scaffolds, inhibitors, amino acids, carbohydrates, peptides, coupling reagents and other compounds.

Enzerna Biosciences is developing a gene therapy approach, called ASRE, for the treatment nucleotide expansion disorders, such as Huntington’s Disease and Myotonic Dystrophy, which cannot be addressed using current CRISPR/Cas technology.

Glycan Therapeutics offers synthetic carbohydrates of various lengths to aid researchers investigating multiple therapeutic areas. Glycan also offers custom synthesis and array analysis of heparan and chondroitin sulfate oligosaccharides derivatives.

Helix3 is a GLP contract research laboratory that designs and conducts customized in vitro and in vivo laboratory services. Helix3's services include regulated studies, screening studies, study design and evaluation, and method development.

Icagen partners with global pharmaceutical and biotech companies to generate high-quality, advanced leads, with expertise in kinases, GPCR’s, ion channels and transporters.

Intarcia Therapeutics is developing a continuous subcutaneous delivery system for the treatment of Type 2 diabetes. The RTP location discovers and develops peptide therapeutic drugs to augment Intarcia's drug delivery platform.

Isosceles Pharmaceuticals is developing parenteral products for delivery of synthetic CBD to treat pain.

LigaTrap Technologies provides proprietary affinity chromatography resins and supporting products. LigaTrap also provides custom services for process development, small batch cell culture, scale up purification and assays.

MedKoo supplies drug substances and bioactive molecules for life-science and biomedical study,

NanoMedica provides ultrasensitive detection reagents and nanotechnology-based drug discovery services and tools to biopharmaceutical companies as well as DNA and RNA sequencing services.

Novex Innovations is a contract development and manufacturing organization (CDMO) supporting small and startup life science companies in the development of their products, from concept through manufacturing and commercialization.

Parion Sciences develops therapies to treat defects of the innate mucosal defense system in respiratory and ophthalmology diseases.

Piedmont Animal Health develops, licenses and markets animal health therapeutics with a focus on major companion animal categories.

Raybow Pharmaceutical conducts contract research and development in organic chemistry for industries including pharma/biotech and electronics. Raybow also offers cGMP services including clinical trial materials supply and low-volume API manufacturing.

Rescindo Therapeutics discovers novel therapeutic targets and drugs for human genetic disorders based on humanized zebrafish in vivo modeling.

RTI Health Solutions is a nonprofit organization that provides biopharmaceutical and medical device companies with clinical research services and research and consulting in health economics, outcomes research, market access, epidemiology and drug safety.

SeaTox Research develops bioassays for the detection of marine toxins and conducts pharmaceutical development through bioprospecting.

Spirovation is a specialty CRO with a focus on the development of breakthrough drugs in respiratory medicine. Spirovation is non-profit, UNC-affiliated entity.

Symmetry Biosciences provides contract research, specialized chemistry services and bioanalytic services to the biotech, pharmaceutical, medical device, agrochemical and fine chemical industries.

Thermo Fisher’s Pharma Services Division offers drug development and manufacturing. Its Greenville site manufactures sterile injectables, tablets and capsules. It also offers stability storage and testing, and API and large-molecule development.

Vijaya Pharmaceuticals provides medicinal and synthetic organic chemistry services to the pharmaceutical and allied industries.