Proteins and Enzymes

StrideBio develops engineered viral vectors for gene therapy for the treatment of rare diseases. StrideBio's technology engine utilizes structure-inspired design to engineer AAV vectors which can escape pre-existing neutralizing antibodies (NAbs).

Asetas Pharma develops novel diagnostic imaging and disease-modifying therapeutic agents to enable the early treatment and reversal of Alzheimer’s and Parkinson’s disease when clinical signs are not yet pronounced.

AgBiome uses its proprietary Genesis platform to collect, isolate and analyze microbes for use in the discovery and development of biologicals and traits for protecting crops and is researching probiotic products to address swine gut health challenges.

Alcami provides contract drug and biologics development and manufacturing services, including formulation development, analytical chemistry, API, solid dose and parenteral drug manufacturing for clinical and commercial markets. Alcami's HQ is in Durham.

Altavant is a clinical stage biopharmaceutical company developing therapies for rare respiratory diseases. Altavant's therapeutic focus is in pulmonary arterial hypertension (PAH) and bronchiolitis obliterans syndrome (BOS).

Asklepios BioPharmaceutical (AskBio) uses adeno-associated virus (AAV) technology to develop and manufacture gene therapies for rare diseases and other genetic disorders.

Avazyme provides field and GLP laboratory testing for sectors including agchem, agbiotech, food and beverage producers and retailers, and pharmaceuticals. Capabilities include mass spectrometry, immunochemistry, microbiology and molecular biology.

BASF's Agricultural Solutions division conducts seeds, traits and plant biotechnology research with a focus on yield and quality traits in major crops. Its RTP campus also houses a bee care center.

Bioantigen Validation provides food safety and environmental microbiology testing services.

Biogen discovers, develops and manufactures therapies for serious neurological diseases. This site houses oral solid dose and anti-sense oligonucleotide production, packaging and fill/finish operations, as well as a Global Business Services center.

BioMarck develops drugs to treat pulmonary diseases and disorders, such as chronic obstructive pulmonary disease, ARDS, cystic fibrosis and lung cancer.

BioResource International (BRI) designs, develops and manufactures unique enzymes that help poultry and swine producers optimize animal nutrition and gut health.

Biotech Restorations formulates bioremediation products for the cleanup of petroleum and chlorinated hydrocarbons including gasoline and diesel, organochloride pesticides, PCBs and volatile organic chemicals in soil, sediment and groundwater.

BioZyme develops and sells substrates for metalloproteinases (MMPs and ADAMs) which can be used in enzyme assays and other diagnostic tests.

CardioEphEx develops therapeutics for cardiovascular disease and heart failure. The company's research focuses on cardioprotection by targeting the Ephrin/Eph receptor signaling pathway in the heart.

Cellective BioTherapy is developing cellular and monoclonal antibody-based platforms for treating cancers, autoimmunity and immunodeficiency through the manipulation of B cells and their functional subsets.

CELLF-Bio is developing a novel regenerative medicine-based therapy for fecal incontinence.

Chaperone Therapeutics develops disease-modifying therapies for neurodegenerative and rare diseases caused by protein misfolding.

Chirazyme produces chloroperoxidase for use in a variety of assays and in stereospecific epoxidation reactions.

Couragen Biopharmaceutics develops gene and protein therapy products for preclinical and clinical use for the treatment of genetic and chronic diseases. Couragen also provides custom adeno-associated virus vectors as a tool for laboratory research.

Cygnus Technologies, part of Maravai LifeSciences, develops products and services for the biopharma industry, including host cell protein (HCP) and other process-related impurity detection and analytics as well as viral clearance solutions.

EpiCypher develops and manufactures novel products and tools for epigenetics and chromatin biology, focused on enabling drug discovery research and development.

Eurofins Craft Technologies provides analytical and method development services to measure nutritional components in blood, tissues, dietary supplements, food and animal feed.

Fujifilm Diosynth Biotechnologies provides biologics contract development and manufacturing. Services include cell line development, process and analytical development, clinical and commercial manufacturing and bioprocess research and development.

GEM Tox Labs conducts research focused on cancer biotechnology, food safety and toxicology, with a special emphasis on cancer biomarker discovery and validation.

Glycan Therapeutics offers synthetic carbohydrates of various lengths to aid researchers investigating multiple therapeutic areas. Glycan also offers custom synthesis and array analysis of heparan and chondroitin sulfate oligosaccharides derivatives.

Huvepharma manufactures Coccidiosis vaccines for in ovo and post-hatch vaccination of poultry.

Immune Diagnostics provides advanced testing services to developers of immuno-therapeutics and vaccines using its proprietary technologies. The company's pipeline includes related clinical diagnostics, point-of-care and companion assays and systems.

Inanovate has developed a patented blood analysis system (the Bio-ID) for diagnostic tests. The first application of the Bio-ID is a new blood test to detect breast cancer recurrence at a stage when it may still be cured.

Initos Pharmaceuticals is developing a platform delivery technology for nucleic acid therapeutics to develop agents to enhance intracellular delivery of oligonucleotides, peptides and proteins.

InSomaBio is developing recombinant, protein-based materials to solve problems in tissue engineering and regenerative medicine.

Isolere Bio is developing novel, non-chromatographic technologies for the purification of biologics such as antibodies, gene delivery vectors and personalized cell therapies.

KAIO Therapy develops an immunotherapy technology to treat solid tumors.

KBI Biopharma offers contract development and biopharmaceutical manufacturing services. This site is KBI's process development facility.

KXTbio develops and commercializes reagents and assays for two major classes of drug targets, GTPases and G protein-coupled receptors.

Laudiss Labs uses advanced proprietary platform technologies for quantitative DNA and protein testing of GMOs, foodborne pathogens and mycotoxins in food and feed.

LeafPro develops new technologies for producing naturally occurring proteins and coproducts from plant biomass.

LigaTrap Technologies provides proprietary affinity chromatography resins and supporting products. LigaTrap also provides custom services for process development, small batch cell culture, scale up purification and assays.

Liquidia Technologies develops and commercializes human therapeutics for the treatment of pulmonary arterial hypertension and post-operative pain using its proprietary particle engineering technology.

Medicago develops vaccines based on proprietary manufacturing technologies and virus-like particles. The vaccines are manufactured using a transient protein expression system in Nicotiana benthamiana, a close relative of tobacco.

Mycosynthetix manages a large collection of fungal isolates and discovers novel fungal metabolites for human and animal health and compounds for agricultural applications.

Nitta Gelatin's Fayetteville plant produces 3,000 tons of pharmaceutical and food-grade gelatins per year. Nitta Gelatin provides many different grades of gelatin for a variety of uses in the pharmaceutical industry.

Novex Innovations is a contract development and manufacturing organization (CDMO) supporting medium, small and startup life science companies in the development of their products, from concept through manufacturing and commercialization.

Novozymes researches, develops and manufactures enzymes, microorganisms and biopharmaceutical ingredients used in industries including agriculture, baking, biofuels, brewing, detergents, food, feed and textiles. The Franklinton site manufactures enzymes.

Parion Sciences develops therapies to treat defects of the innate mucosal defense system in respiratory and ophthalmology diseases.

Plakous Therapeutics is developing biotherapeutics from post-delivery placenta to promote regenerative healing for diseases including osteoarthritis, necrotizing enterocolitis, wound healing and tissue engraftment.

QCL offers both large and small molecule analytical and microbiological testing, including raw-materials and finished-products, stability storage & testing, method development/validation, formulation development and clinical manufacturing/packaging.

RiboWiz Scientific uses a proprietary platform to offer customized software services and cloud-based subscription licensing to accurately predict and maximize protein production for life science companies.

Sanesco develops clinical tools for healthcare providers, such as neuroendocrine analytical testing, nutritional support formulas and patient-centered clinical review. The NeuroLab division conducts research and development of in vitro diagnostic tools.