Proteins and Enzymes

Biomanufacturing Research Institute & Technology Enterprise (BRITE) is hands-on education and training program at NC Central University that focuses on teaching the process of drug development.

AC Thera is developing drugs to neutralize bacterial toxins for the treatment of diseases with high mortality.

Affinergy develops peptide-based technologies, including diagnostic products, research tools and therapeutic drug monitoring products for use by clinicians and researchers.

Alcami provides contract drug and biologics development and manufacturing services, including formulation development, analytical chemistry, API, solid dose and parenteral drug manufacturing for both clinical and commercial markets.

Alera Labs provides contract research analytical chemistry, in vitro toxicology, GLP analysis and preformulation services to pharmaceutical, biotech and medical device companies.

The Division of Therapeutic Research and Development at Atrium Health conducts clinical studies, patient-focused translational research and outcomes research.

Avioq develops and manufactures FDA-approved and CE-marked immunodiagnostic assays. Products include HIV and HTLV assays, recombinant proteins and synthetic peptides and labware supplies. Avioq also offers contract IVD development and manufacturing.

BASF's Agricultural Solutions division conducts seeds, traits and plant biotechnology research with a focus on yield and quality traits in major crops. Its RTP campus also houses a bee care center.

Biogen discovers, develops and manufactures therapies for serious neurological diseases. Its Drug Substance Campus in RTP is home to biologics production and a patient services contact center.

BioGreen Synergy manufactures, grows and provides algae-based products for use in alternative renewable energies, USDA, non-USDA and chemical markets.

BioMedomics develops point-of-care (POC) diagnostics, with a focus on immunologically-based disease-specific tests and advanced quantitative POC platforms.

Biotech Restorations formulates bioremediation products for the cleanup of petroleum and chlorinated hydrocarbons including gasoline and diesel, organochloride pesticides, PCBs and volatile organic chemicals in soil, sediment and groundwater.

BioZyme develops and sells substrates for metalloproteinases (MMPs and ADAMs) which can be used in enzyme assays and other diagnostic tests.

CardioEphEx develops therapeutics for cardiovascular disease and heart failure. The company's research focuses on cardioprotection by targeting the Ephrin/Eph receptor signaling pathway in the heart.

Cellex develops, manufactures and markets diagnostic tests suitable for point-of-care use. These tests use a platform technology called Homogeneous Biochemiluminescence Assay (HBA), which enables assays that are highly sensitive and easy-to-use.

Chaperone Therapeutics develops disease-modifying therapies for neurodegenerative and rare diseases caused by protein misfolding.

CHD Technologies conducts chemical process R&D for agricultural and pharmaceutical intermediates. Competencies include distillation, rectification, crystallization, filtration and drying for batch and continuous chemical manufacturing processes.

Cognosci develops neurorestorative therapies for Alzheimer's disease, multiple sclerosis, traumatic brain injury, nerve crush and other disease and trauma indications.

Cygnus Technologies develops products and services for the biopharma industry, including host cell protein ELISA kits, immunoassay reagents and custom development of antibodies and assays.

Dualogics researches and develops bispecific antibody products based on their proprietary OrthoMab platform.

EpiCypher develops and manufactures novel products and tools for epigenetics and chromatin biology, focused on enabling drug discovery research and development.

Eurofins Craft Technologies provides analytical and method development services to measure nutritional components in blood, tissues, dietary supplements, food and animal feed.

Fujifilm Diosynth Biotechnologies provides biologics contract development and manufacturing. Services include cell line development, process and analytical development, clinical and commercial manufacturing and bioprocess research and development.

GEM Tox Labs conducts research focused on cancer biotechnology, food safety and toxicology, with a special emphasis on cancer biomarker discovery and validation.

BTEC provides hands-on education and training in bioprocessing and cGMP compliance to university students and industry employees. Faculty and staff also engage in process development activities in the 82,500 gsf facility.

Grifols' Clayton plant is the company's primary manufacturing facility, producing proteins to treat rare diseases including immune deficiencies and genetic emphysema.

Ideal Health Biotechnology researches and develops dietary supplements made from plant-based compounds, including products derived from grape seed extract and algae for digestion, eye disease and diabetes.

Inanovate has developed a patented blood analysis system (the Bio-ID) for diagnostic tests. The first application of the Bio-ID is a new blood test to detect breast cancer recurrence at a stage when it may still be cured.

Initos Pharmaceuticals is developing a platform delivery technology for nucleic acid therapeutics to develop agents to enhance intracellular delivery of oligonucleotides, peptides and proteins.

Innovate Biopharmaceuticals develops novel medicines for autoimmune and inflammatory diseases with unmet needs, including drug candidates for celiac disease and NASH.

Isolere Bio is developing novel, non-chromatographic technologies for the purification of biologics such as antibodies, gene delivery vectors and personalized cell therapies.

Jericho Sciences is developing antiviral therapeutics and corresponding personalized diagnostics for the clinical management of HIV-1 infection.

KBI Biopharma offers contract development and biopharmaceutical manufacturing services such as formulation, analytical method development, stability services, process development and recombinant protein API manufacturing. This site is KBI's headquarters.

Keratin Biosciences advances regenerative medicine and drug delivery therapies for tissue injuries based on human-derived keratin technology platform. This site manufactures biomaterials for thermal burns, and bone, muscle and nerve regeneration.

LabCorp's Center for Molecular Biology and Pathology provides laboratory testing services. The company’s expertise is focused in diagnostic genetics, oncology and pathology.

LCMS provides LC/MS services for the identification and quantification of compounds in biological and environmental matrices. LCMS specializes in detecting cross contamination from food and drug manufacturing and also provides LC/MS training.

LifeEDIT, an AgBiome subsidiary, uses its bioinformatic pipeline to mine a microbial genome sequence database to develop gene editing systems. Systems are used in therapeutic and agriculture gene editing applications in-house and through partnerships.

Lindy Biosciences develops protein therapeutic formulations for non-standard formulations such as suspension formulations (for high-concentration delivery of antibodies), encapsulation (for sustained/controlled release) or dry powder pulmonary delivery.

MARBIONC Development Group is a nonprofit organization that develops and markets new products and technologies derived from marine and aquatic organisms.

MEDTOX Diagnostics manufactures and distributes instant drugs of abuse testing devices for use by the government, hospital and medical centers and workplace markets.

Mycosynthetix manages a large collection of fungal isolates and discovers novel fungal metabolites for human and animal health and compounds for agricultural applications.

NanoMedica provides ultrasensitive detection reagents and nanotechnology-based drug discovery services and tools to biopharmaceutical companies as well as DNA and RNA sequencing services.

Nitta Gelatin manufactures food, pharmaceutical and technical gelatin, and is the maker of beMatrix Low Endotoxin Gelatin. beMatrix is used in the fields of regenerative medicine, medical devices and scientific research.

Noah’s Inc. develops algal growth systems and cultivates algal biomass for the manufacture of protein, astaxanthin and other derivatives for use as nutraceutical ingredients in food and beverage industries, and for commercial fish/animal feed industries.

Novozymes BioAg develops microbial-based biofertility, biocontrol and bioyield enhancer products for agriculture. The Morrisville site focuses on fermentation and production technology.

Parion Sciences develops therapies to treat defects of the innate mucosal defense system in respiratory and ophthalmology diseases.

Plakous Therapeutics is developing biotherapeutics from post-delivery placenta to promote regenerative healing for diseases including osteoarthritis, necrotizing enterocolitis, wound healing and tissue engraftment.

Precision BioSciences utilizes a proprietary genome editing method called ARCUS to treat cancers and genetic diseases, and enable the development of safer, more productive food sources.

Rescindo Therapeutics discovers novel therapeutic targets and drugs for human genetic disorders based on humanized zebrafish in vivo modeling.